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| 编 号 | 规格 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D163046-0025 | 25 ul | 现货 | 待询价 | 待询价 | |
| D163046-0100 | 100 ul | 现货 | 待询价 | 待询价 | |
| D163046-0200 | 200 ul | 现货 | 待询价 | 待询价 |
概述
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | P23458 |
| 靶点基因 ID | 3716 |
| 靶点全称 | Janus kinase 1 |
| 靶点别名 | JTK3; JAK1A; JAK1B |
| 靶点研究领域 | Signal Transduction, Epigenetics and Nuclear Signaling, Cancer |
| 亚型 | Immunogen-specific rabbit IgG |
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