Order NO. D163374
兔抗PRKACA多克隆抗体
| 英文名 | Anti-PRKACA rabbit polyclonal antibody | ||
| 别名 | PKACA; PPNAD4 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse, Rat |
| 标记物 | Unconjugate | 克隆类型 | rabbit polyclonal |
| 抗原 | PRKACA | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D163374-0025 | 25 ul | 现货 |
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| D163374-0100 | 100 ul | 现货 |
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| D163374-0200 | 200 ul | 现货 |
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属性
| Background: | This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015] (The background information is obtained from official databases and does not represent the product information.) |
| Applications: | ELISA, WB, IHC |
| Name of antibody: | PRKACA |
| Immunogen: | Synthetic peptide of human PRKACA |
| Full name: | protein kinase cAMP-activated catalytic subunit alpha |
| Synonyms: | CAFD1; PKACA; PPNAD4 |
| SwissProt: | P17612 |
| ELISA Recommended dilution: | 5000-10000 |
| IHC positive control: | Human liver cancer and Human brain |
| IHC Recommend dilution: | 25-100 |
| WB Predicted band size: | 41 kDa |
| WB Positive control: | MCF7, TM4 cell lysates |
| WB Recommended dilution: | 1000-5000 |
相关文档
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Sample Application
