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Order NO. D164609
兔抗CFI多克隆抗体
| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D164609-0025 | 25 ul | 现货 |
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| D164609-0100 | 100 ul | 现货 |
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| D164609-0200 | 200 ul | 现货 |
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属性
| Background: | This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. |
| Applications: | ELISA, WB, IHC |
| Name of antibody: | CFI |
| Immunogen: | Synthetic peptide of human CFI |
| Full name: | complement factor I |
| Synonyms: | FI; IF; KAF; AHUS3; ARMD13; C3BINA; C3b-INA |
| SwissProt: | P05156 |
| ELISA Recommended dilution: | 5000-10000 |
| IHC positive control: | Human gastric cancer and Human bladder cancer |
| IHC Recommend dilution: | 50-200 |
| WB Predicted band size: | 66 kDa |
| WB Positive control: | HepG2 cell, Mouse lung tissue lysates |
| WB Recommended dilution: | 500-2000 |
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