概述

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

应用

免疫检测

属性

保存缓冲液	-20°C, 0.01M PBS (pH7.4). Avoid repeated freeze-thaw cycles.
运输条件	2-8°C
靶点 Uniprot 登记号	P08575
靶点基因 ID	5788
靶点全称	protein tyrosine phosphatase receptor type C
靶点别名	protein tyrosine phosphatase receptor type C; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
靶点研究领域	Signal Transduction, Neuroscience, Cardiovascular, Immunology, Stem Cells
亚型	IgG2a