Order NO. D190612
产品描述
概述
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
应用
免疫印迹(WB),免疫沉淀(IP)
属性
保存缓冲液 |
-20°C, buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P56524
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靶点基因 ID |
9759
|
靶点全称 |
histone deacetylase 4
|
靶点别名 |
HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A
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靶点研究领域 |
Epigenetics and Nuclear Signaling, Cardiovascular, Signal Transduction
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亚型 |
IgG2a
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