Order NO. D190773
产品描述
概述
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
应用
免疫印迹(WB),免疫荧光(IF)
属性
保存缓冲液 |
-20°C, PBS(pH 7.4) containing 0.03% Proclin300 and 50% glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P45983
|
靶点基因 ID |
5599
|
靶点全称 |
mitogen-activated protein kinase 8
|
靶点别名 |
JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
|
靶点研究领域 |
Signal Transduction, Cancer, Immunology
|
亚型 |
IgG2a
|