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Order NO. D190773
小鼠抗MAPK8单克隆抗体
英文名 Anti-MAPK8 mouse monoclonal antibody
别名 mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
相关类别 一抗 储存 冷冻(-20℃)
宿主 Mouse 反应种属 Human, Mouse, Rat
克隆类型 Mouse Monoclonal 抗原 MAPK8
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D190773-0050 50 ul 预计5日内发货
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D190773-0100 100 ul 预计5日内发货
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产品描述

概述

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

应用

免疫印迹(WB),免疫荧光(IF)

属性

保存缓冲液 -20°C, PBS(pH 7.4) containing 0.03% Proclin300 and 50% glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 P45983
靶点基因 ID 5599
靶点全称 mitogen-activated protein kinase 8
靶点别名 JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
靶点研究领域 Signal Transduction, Cancer, Immunology
亚型 IgG2a
Sample Application

  • The image is immunofluorescence of 3T3 cells fixed by anhydrous methanol for 2h at -20°C using D190773(MAPK8 Antibody) at dilution 1/100.

  • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane 1-2: C6 and 3T3 cell lysates , Primary antibody: D190773(MAPK8 Antibody) at dilution 1/1000, Secondary antibody: Goat anti mouse IgG at 1/8000 dilution, Exposure time: 5 minutes
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