Order NO. D190782
产品描述
概述
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
应用
免疫印迹(WB),免疫沉淀(IP)
属性
保存缓冲液 |
-20°C, PBS(pH 7.4) containing 0.02% sodium azide and 50% glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q96EB6
|
靶点基因 ID |
23411
|
靶点全称 |
sirtuin 1
|
靶点别名 |
SIR2; SIR2L1; SIR2alpha
|
靶点研究领域 |
Epigenetics and Nuclear Signaling, Metabolism, Cancer
|
亚型 |
IgG2b
|