Order NO. D190795
产品描述
概述
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
应用
免疫印迹(WB),免疫荧光(IF),免疫沉淀(IP)
属性
保存缓冲液 |
-20°C, PBS(pH 7.4) containing 0.03% Proclin300 and 50% glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P05198
|
靶点基因 ID |
1965
|
靶点全称 |
eukaryotic translation initiation factor 2 subunit alpha
|
靶点别名 |
EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha
|
靶点研究领域 |
Epigenetics and Nuclear Signaling
|
亚型 |
IgG2b
|