概述

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.

应用

免疫检测

属性

保存缓冲液	-20°C, 0.01M PBS (pH7.4), 0.15M NaCl. Avoid repeated freeze-thaw cycles.
运输条件	2-8°C
靶点 Uniprot 登记号	P02771
靶点基因 ID	174
靶点全称	alpha fetoprotein
靶点别名	alpha fetoprotein; AFPD; FETA; HPAFP; 甲胎蛋白
靶点研究领域	Cancer, Cardiovascular, Developmental Biology
亚型	IgG1