概述

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.

应用

免疫检测，免疫组织化学（IHC）

属性

保存缓冲液	-20°C, 0.01M PBS (pH7.4), 0.15M NaCl. Avoid repeated freeze-thaw cycles.
运输条件	2-8°C
靶点 Uniprot 登记号	P07288
靶点基因 ID	354
靶点全称	kallikrein related peptidase 3
靶点别名	kallikrein related peptidase 3; APS; PSA; hK3; KLK2A1; Prostate Specific Antigen; 前列腺特异性抗原
靶点研究领域	Signal Transduction, Cancer, Neuroscience
亚型	IgG