概述

This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.

应用

酶联免疫吸附测定（ELISA），免疫印迹（WB）

属性

保存缓冲液	-20°C, 0.01M PBS (pH7.4), 0.15M NaCl, 0.05% NaN3. Avoid repeated freeze-thaw cycles.
运输条件	2-8°C
靶点 Uniprot 登记号	Q8WXI7
靶点基因 ID	94025
靶点全称	mucin 16, cell surface associated
靶点别名	mucin 16, cell surface associated; CA125; CA 125; Cancer Antigen 125; Carbohydrate Antigen 125; 癌抗原125; 糖链抗原125
靶点研究领域	Cell Markers, Signal Transduction, Cancer
亚型	IgG1