概述

25-hydroxyvitamin D3 (25(OH)D3) is synthesized in the liver and is the primary circulating form of vitamin D. Its blood concentration, which reflects 25(OH)D3 produced by exposure to ultraviolet B, as well as dietary and vitamin D supplementation, is felt to be the best indicator of vitamin D status. 25(OH)D3 is metabolized to 1 alpha,25(OH)2D3 in the proximal tubular cells of the kidney by the enzyme 1 alpha -hydroxylase. The vitamin D structure is similar to that of classic steroid hormones, such as estradiol, cortisol, and aldosterone in that they have the same root cyclopentanoperhydrophenanthrene ring structure. It has been shown that the active steroid hormone 1 alpha,25(OH)2D3 is essential for life in higher animals. Besides playing important roles in calcium homeostasis and bone mineral metabolism, it is now known to play a role in cellular differentiation, inhibition of cell growth, immune regulation and the prevention of neoplastic transformation.

应用

酶联免疫吸附测定（ELISA）

属性

保存缓冲液	-20°C, 0.01M PBS (pH7.4). Avoid repeated freeze-thaw cycles.
运输条件	2-8°C
靶点全称	25-hydroxyvitamin D3
靶点别名	25-hydroxyvitamin D3; 25(OH)-D3; 25(OH)D3; Calcifediol; 25-羟维生素D3
靶点研究领域	Cardiovascular, Signal Transduction, Cell Biology, Cancer, Metabolism
亚型	IgG