Order NO. D194530
产品描述
概述
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
应用
免疫印迹(WB), 免疫荧光(IF)
属性
保存缓冲液 |
-20°C, PBS (PH 7.4) containing 0.05% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P12644
|
靶点基因 ID |
652
|
靶点全称 |
bone morphogenetic protein 4
|
靶点别名 |
ZYME; BMP2B; OFC11; BMP2B1; MCOPS6
|
靶点研究领域 |
Signal Transduction, Cancer, Cardiovascular, Developmental Biology
|
亚型 |
IgG1
|