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Order NO. D194612
小鼠抗GRIA2单克隆抗体
英文名 Anti-GRIA2 mouse monoclonal antibody
别名 glutamate ionotropic receptor AMPA type subunit 2; GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2
相关类别 一抗 储存 冷冻(-20℃)
宿主 Mouse 反应种属 Human
克隆类型 mouse monoclonal 抗原 GRIA2
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D194612-0050 50 ul 预计5日内发货
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D194612-0100 100 ul 预计5日内发货
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产品描述

概述

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.

应用

免疫印迹(WB),流式细胞术(FCM)

属性

保存缓冲液 -20°C, PBS (PH 7.4) containing 0.05% sodium azide.
运输条件 2-8°C
靶点 Uniprot 登记号 P42262
靶点基因 ID 2891
靶点全称 glutamate ionotropic receptor AMPA type subunit 2
靶点别名 GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2
靶点研究领域 Neuroscience
亚型 IgG1
相关文档
Sample Application

  • The image is flow cytometry analysis of SK-N-SH cells using D194612(GRIA2 antibody) at dilution 1/400 (green) and negative control (red).

  • Gel: 6%SDS-PAGE, Lysate: 20 μg, Lane: Hela cell lysate, Primary antibody: D194612(GRIA2 Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti mouse IgG at 1/10000 dilution, Exposure time: 2 minutes
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