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Order NO. D194614
小鼠抗GSTM1单克隆抗体
英文名 Anti-GSTM1 mouse monoclonal antibody
别名 glutathione S-transferase mu 1; MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b
相关类别 一抗 储存 冷冻(-20℃)
宿主 Mouse 反应种属 Human, Monkey
克隆类型 mouse monoclonal 抗原 GSTM1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D194614-0050 50 ul 预计5日内发货
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D194614-0100 100 ul 预计5日内发货
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产品描述

概述

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.

应用

免疫印迹(WB),免疫组织化学(IHC),流式细胞术(FCM)

属性

保存缓冲液 -20°C, Ascitic fluid with 0.05% sodium azide
运输条件 2-8°C
靶点 Uniprot 登记号 P09488
靶点基因 ID 2944
靶点全称 glutathione S-transferase mu 1
靶点别名 MU; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1; GSTM1a-1a; GSTM1b-1b
靶点研究领域 Signal Transduction, Metabolism
亚型 IgG1
相关文档
Sample Application

  • The image is flow cytometry analysis of Jurkat cells using D194614(GSTM1 antibody) at dilution 1/400 (green) and negative control (red).

  • The image is immunohistochemistry of paraffin-embedded Human rectum cancer tissue using D194614(GSTM1 Antibody) at dilution 1/800. (Original magnification: ×200)

  • The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using D194614(GSTM1 Antibody) at dilution 1/800. (Original magnification: ×200)

  • Gel: 12%SDS-PAGE, Lysate: 20 μg, Lane 1-6: COS-7, MCF-7, Jurkat, Hela, HL-7702 and HepG2 cell lysates, Primary antibody: D194614(GSTM1 Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti mouse IgG at 1/10000 dilution, Exposure time: 2 minutes
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