Order NO. D194700
产品描述
概述
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
应用
免疫印迹（WB），免疫组织化学（IHC），流式细胞术（FCM）
属性
| 保存缓冲液 |
-20°C, PBS (PH 7.4) containing 0.05% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P54646
|
| 靶点基因 ID |
5563
|
| 靶点全称 |
protein kinase AMP-activated catalytic subunit alpha 2
|
| 靶点别名 |
AMPK; AMPK2; PRKAA; AMPKa2
|
| 靶点研究领域 |
Signal Transduction, Cancer, Metabolism, Cardiovascular
|
| 亚型 |
IgG1
|
