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Order NO. D194773
小鼠抗SMAD3单克隆抗体
英文名 Anti-SMAD3 mouse monoclonal antibody
别名 SMAD family member 3; LDS3; mad3; LDS1C; MADH3; JV15-2; hMAD-3; hSMAD3; HSPC193; HsT17436
相关类别 一抗 储存 冷冻(-20℃)
宿主 Mouse 反应种属 Human, Mouse
克隆类型 mouse monoclonal 抗原 SMAD3
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D194773-0050 50 ul 预计5日内发货
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D194773-0100 100 ul 预计5日内发货
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产品描述

概述

The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3.

应用

免疫印迹(WB), 免疫荧光(IF)

属性

保存缓冲液 -20°C, Ascitic fluid with 0.05% sodium azide
运输条件 2-8°C
靶点 Uniprot 登记号 P84022
靶点基因 ID 4088
靶点全称 SMAD family member 3
靶点别名 LDS3; mad3; LDS1C; MADH3; JV15-2; hMAD-3; hSMAD3; HSPC193; HsT17436
靶点研究领域 Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Cardiovascular, Metabolism
亚型 IgG1
相关文档
Sample Application

  • The image is immunofluorescence of NIH/3T3 cells using D194773(SMAD3 Antibody) at dilution 1/200 (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

  • Gel: 8%SDS-PAGE, Lysate: 20 μg, Lane 1-5: A549, Hela, Jurkat, PC-2 and NIH/3T3 cell lysates, Primary antibody: D194773(SMAD3 Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti mouse IgG at 1/10000 dilution, Exposure time: 2 minutes
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