Order NO. D194903
产品描述
概述
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
应用
免疫印迹(WB),免疫组织化学(IHC),流式细胞术(FCM)
属性
保存缓冲液 |
-20°C, PBS (PH 7.4) containing 0.05% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P17813
|
靶点基因 ID |
2022
|
靶点全称 |
endoglin
|
靶点别名 |
END; HHT1; ORW1
|
靶点研究领域 |
Cancer, Cardiovascular, Immunology, Stem Cells
|
亚型 |
IgG1
|