Order NO. D194920
小鼠抗MLH1单克隆抗体
| 英文名 | Anti-MLH1 mouse monoclonal antibody | ||
| 别名 | mutL homolog 1; FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; MMRCS1 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Mouse | 反应种属 | Human |
| 克隆类型 | mouse monoclonal | 抗原 | MLH1 |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D194920-0050 | 50 ul | 预计5日内发货 |
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| D194920-0100 | 100 ul | 预计5日内发货 |
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产品描述
概述
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
应用
免疫印迹（WB），免疫组织化学（IHC），流式细胞术（FCM）
属性
| 保存缓冲液 | -20°C, PBS (PH 7.4) containing 0.05% sodium azide. |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | P40692 |
| 靶点基因 ID | 4292 |
| 靶点全称 | mutL homolog 1 |
| 靶点别名 | FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; MMRCS1 |
| 靶点研究领域 | Epigenetics and Nuclear Signaling, Cancer |
| 亚型 | IgG1 |
相关文档
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Sample Application
