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Order NO. D194920
小鼠抗MLH1单克隆抗体
英文名 Anti-MLH1 mouse monoclonal antibody
别名 mutL homolog 1; FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; MMRCS1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Mouse 反应种属 Human
克隆类型 mouse monoclonal 抗原 MLH1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D194920-0050 50 ul 预计5日内发货
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D194920-0100 100 ul 预计5日内发货
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产品描述

概述

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).

应用

免疫印迹(WB),免疫组织化学(IHC),流式细胞术(FCM)

属性

保存缓冲液 -20°C, PBS (PH 7.4) containing 0.05% sodium azide.
运输条件 2-8°C
靶点 Uniprot 登记号 P40692
靶点基因 ID 4292
靶点全称 mutL homolog 1
靶点别名 FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; MMRCS1
靶点研究领域 Epigenetics and Nuclear Signaling, Cancer
亚型 IgG1
相关文档
Sample Application

  • The image is flow cytometry analysis of Hela cells using D194920(MLH1 antibody) at dilution 1/400 (green) and negative control (red).

  • The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using D194920(MLH1 Antibody) at dilution 1/800. (Original magnification: ×200)

  • The image is immunohistochemistry of paraffin-embedded Human bladder cancer tissue using D194920(MLH1 Antibody) at dilution 1/800. (Original magnification: ×200)

  • Gel: 6%SDS-PAGE, Lysate: 20 μg, Lane 1-5: Hela, Jurkat, A431, HepG2 and MCF-7 cell lysates, Primary antibody: D194920(MLH1 Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti mouse IgG at 1/10000 dilution, Exposure time: 2 minutes
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