Order NO. D194920
产品描述
概述
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
应用
免疫印迹(WB),免疫组织化学(IHC),流式细胞术(FCM)
属性
保存缓冲液 |
-20°C, PBS (PH 7.4) containing 0.05% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P40692
|
靶点基因 ID |
4292
|
靶点全称 |
mutL homolog 1
|
靶点别名 |
FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; MMRCS1
|
靶点研究领域 |
Epigenetics and Nuclear Signaling, Cancer
|
亚型 |
IgG1
|