Order NO. D194924
产品描述
概述
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
应用
免疫印迹（WB）, 免疫组织化学（IHC）, 免疫荧光（IF）, 流式细胞术（FCM）
属性
| 保存缓冲液 |
-20°C, Ascitic fluid with 0.05% sodium azide
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P19838
|
| 靶点基因 ID |
4790
|
| 靶点全称 |
nuclear factor kappa B subunit 1
|
| 靶点别名 |
KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta
|
| 靶点研究领域 |
Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Immunology
|
| 亚型 |
IgG2a
|
