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| 编 号 | 规格 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D194924-0050 | 50 ul | 预计5日内发货 | 待询价 | 待询价 |
|
| D194924-0100 | 100 ul | 预计5日内发货 | 待询价 | 待询价 |
|
概述
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
应用
免疫印迹（WB）, 免疫组织化学（IHC）, 免疫荧光（IF）, 流式细胞术（FCM）
属性
| 保存缓冲液 | -20°C, Ascitic fluid with 0.05% sodium azide |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | P19838 |
| 靶点基因 ID | 4790 |
| 靶点全称 | nuclear factor kappa B subunit 1 |
| 靶点别名 | KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta |
| 靶点研究领域 | Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Immunology |
| 亚型 | IgG2a |
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