Order NO. D195417
小鼠抗HRAS/KRAS/NRAS (mutated G12S)单克隆抗体
| 英文名 | Anti-HRAS/KRAS/NRAS (mutated G12S) mouse monoclonal antibody | ||
| 别名 | HRAS/KRAS/NRAS proto-oncogene, GTPase; CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; NS; NS3; OES; CFC | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Mouse | 反应种属 | Recognizes G12S mutant, but not wild-type Human RAS |
| 标记物 | Unconjugate | 克隆类型 | mouse monoclonal |
| 抗原 | HRAS/KRAS/NRAS | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D195417-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | HRAS gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. KRAS gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. NRAS is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. |
| Applications: | ELISA, WB, IF |
| Name of antibody: | HRAS/KRAS/NRAS (mutated G12S) |
| Immunogen: | A synthetic peptide from the internal region of human RAS which includes the mutation of G12S |
| Full name: | HRAS/KRAS/NRAS proto-oncogene, GTPase |
| Synonyms: | CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1; NS; NS3; OES; CFC2; RALD; K-Ras; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; K-Ras 2; 'C-K-RAS; c-Ki-ras; c-Ki-ras2; NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1 |
| SwissProt: | P01112/P01116/P01111 |
| ELISA Recommended dilution: | 1000-5000 |
| WB Predicted band size: | 21 kDa |
| WB Positive control: | Purified His-tagged RAS (mutated G12S) protein |
| WB Recommended dilution: | 500-1000 |
| IF Recommended dilution: | 50-100 |
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