Order NO. D195431
小鼠抗NOTCH1 (mutated M2011R)单克隆抗体
| 英文名 | Anti-NOTCH1 (mutated M2011R) mouse monoclonal antibody | ||
| 别名 | notch receptor 1; hN1; AOS5; TAN1; AOVD1 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Mouse | 反应种属 | Recognizes M2011R mutant, but not wild-type Human NOTCH1 |
| 标记物 | Unconjugate | 克隆类型 | mouse monoclonal |
| 抗原 | NOTCH1 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D195431-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. |
| Applications: | ELISA, WB, IF |
| Name of antibody: | NOTCH1 (mutated M2011R) |
| Immunogen: | A synthetic peptide from the internal region of human NOTCH1 which includes the mutation of M2011R |
| Full name: | notch receptor 1 |
| Synonyms: | hN1; AOS5; TAN1; AOVD1 |
| SwissProt: | P46531 |
| ELISA Recommended dilution: | 1000-2000 |
| WB Predicted band size: | 273 kDa |
| WB Positive control: | Purified His-tagged NOTCH1 (mutated M2011R) protein |
| WB Recommended dilution: | 500-1000 |
| IF Recommended dilution: | 50-100 |
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