Order NO. D195449
小鼠抗IDH1 (mutated R132H)单克隆抗体
| 英文名 | Anti-IDH1 (mutated R132H) mouse monoclonal antibody | ||
| 别名 | isocitrate dehydrogenase (NADP(+)) 1; IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Mouse | 反应种属 | Recognizes IDH1 (mutated R132H) of Human |
| 标记物 | Unconjugate | 克隆类型 | mouse monoclonal |
| 抗原 | IDH1 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D195449-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| Applications: | ELISA, WB, IF |
| Name of antibody: | IDH1 (mutated R132H) |
| Immunogen: | A synthetic peptide from the internal region of human IDH1 which includes the mutation of R132H |
| Full name: | isocitrate dehydrogenase (NADP(+)) 1 |
| Synonyms: | IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26 |
| SwissProt: | O75874 |
| ELISA Recommended dilution: | 1000-5000 |
| WB Predicted band size: | 47 kDa |
| WB Positive control: | Purified His-tagged IDH1 (mutated R132H) protein |
| WB Recommended dilution: | 100-1000 |
| IF Recommended dilution: | 50-100 |
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Sample Application
