Order NO. D195461
小鼠抗KIT (mutated W557R)单克隆抗体
| 英文名 | Anti-KIT (mutated W557R) mouse monoclonal antibody | ||
| 别名 | KIT proto-oncogene, receptor tyrosine kinase; PBT; SCFR; C-Kit; CD117; MASTC | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Mouse | 反应种属 | Recognizes W557R mutant, but not wild-type Human KIT |
| 标记物 | Unconjugate | 克隆类型 | mouse monoclonal |
| 抗原 | KIT | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D195461-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Applications: | ELISA, WB, IF |
| Name of antibody: | KIT (mutated W557R) |
| Immunogen: | A synthetic peptide from the internal region of human KIT which includes the mutation of W557R |
| Full name: | KIT proto-oncogene, receptor tyrosine kinase |
| Synonyms: | PBT; SCFR; C-Kit; CD117; MASTC |
| SwissProt: | P10721 |
| ELISA Recommended dilution: | 1000-5000 |
| WB Predicted band size: | 110 kDa |
| WB Positive control: | Purified His-tagged KIT (mutated W557R) protein |
| WB Recommended dilution: | 500-1000 |
| IF Recommended dilution: | 50-100 |
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Sample Application
