Order NO. D195505
小鼠抗FGFR1 (mutated R576W)单克隆抗体
| 英文名 | Anti-FGFR1 (mutated R576W) mouse monoclonal antibody | ||
| 别名 | fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Mouse | 反应种属 | Recognizes R576W mutant, but not wild-type Human FGFR1 |
| 标记物 | Unconjugate | 克隆类型 | mouse monoclonal |
| 抗原 | FGFR1 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D195505-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. |
| Applications: | ELISA, WB, IF |
| Name of antibody: | FGFR1 (mutated R576W) |
| Immunogen: | A synthetic peptide from the internal region of human FGFR1 which includes the mutation of R576W |
| Full name: | fibroblast growth factor receptor 1 |
| Synonyms: | CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1 |
| SwissProt: | P11362 |
| ELISA Recommended dilution: | 1000-2000 |
| WB Predicted band size: | 92 kDa |
| WB Positive control: | Purified His-tagged FGFR1 (mutated R576W) protein |
| WB Recommended dilution: | 500-1000 |
| IF Recommended dilution: | 50-100 |
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Sample Application
