Order NO. D197005
产品描述
概述
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.
应用
免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q12888
|
靶点基因 ID |
7158
|
靶点全称 |
tumor protein p53 binding protein 1
|
靶点别名 |
TP53; p202; 53BP1; TDRD30; p53BP1
|
靶点研究领域 |
Epigenetics and Nuclear Signaling, Cancer
|
亚型 |
IgG2b
|