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Order NO. D197005
小鼠抗TP53BP1单克隆抗体
英文名 Anti-TP53BP1 mouse monoclonal antibody
别名 tumor protein p53 binding protein 1; TP53; p202; 53BP1; TDRD30; p53BP1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Mouse 反应种属 Human
克隆类型 mouse monoclonal 抗原 TP53BP1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D197005-0100 100 ul 预计5日内发货
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产品描述

概述

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

应用

免疫印迹(WB),免疫组织化学(IHC)

属性

保存缓冲液 PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
运输条件 2-8°C
靶点 Uniprot 登记号 Q12888
靶点基因 ID 7158
靶点全称 tumor protein p53 binding protein 1
靶点别名 TP53; p202; 53BP1; TDRD30; p53BP1
靶点研究领域 Epigenetics and Nuclear Signaling, Cancer
亚型 IgG2b
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human breast tissue, on the right is immunohistochemistry of paraffin-embedded Human breast cancer using D197005(TP53BP1 Antibody) at dilution 1/2000. (Original magnification: ×200)


  • The image on the left is immunohistochemistry of paraffin-embedded Human pancreas tissue, on the right is immunohistochemistry of paraffin-embedded Human endometrium tissue using D197005(TP53BP1 Antibody) at dilution 1/2000. (Original magnification: ×200)


  • Gel: 6%SDS-PAGE, Lysate: 35μg, Lane 1-2: Hela and 293T cell lysates, Primary antibody: D197005(TP53BP1 Antibody) at dilution 1/500, Secondary antibody: Goat anti mouse IgG at 1/5000 dilution, Exposure time: 15 minutes
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