Order NO. D197058
产品描述
概述
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.
应用
免疫印迹(WB)
属性
保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q15637
|
靶点基因 ID |
7536
|
靶点全称 |
splicing factor 1
|
靶点别名 |
BBP; MBBP; ZFM1; ZNF162; D11S636; ZCCHC25
|
靶点研究领域 |
Epigenetics and Nuclear Signaling
|
亚型 |
IgG1
|