Order NO. D197139
产品描述
概述
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9.
应用
免疫印迹（WB），免疫组织化学（IHC）
属性
| 保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
O14818
|
| 靶点基因 ID |
5688
|
| 靶点全称 |
proteasome subunit alpha 7
|
| 靶点别名 |
C6; HSPC; RC6-1; XAPC7; HEL-S-276
|
| 靶点研究领域 |
Immunology, Cell Biology, Stem Cells
|
| 亚型 |
IgG2b
|
