Order NO. D198074
产品描述
概述
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
应用
免疫印迹（WB），免疫组织化学（IHC）
属性
| 保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P62136
|
| 靶点基因 ID |
5499
|
| 靶点全称 |
protein phosphatase 1 catalytic subunit alpha
|
| 靶点别名 |
PP1A; PP-1A; PPP1A; PP1alpha
|
| 靶点研究领域 |
Cancer, Signal Transduction, Metabolism, Epigenetics and Nuclear Signaling
|
| 亚型 |
IgG1
|
