Order NO. D198208
产品描述
概述
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
应用
免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P21912
|
靶点基因 ID |
6390
|
靶点全称 |
succinate dehydrogenase complex iron sulfur subunit B
|
靶点别名 |
IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
|
靶点研究领域 |
Metabolism, Cancer, Cell Biology
|
亚型 |
IgG1
|