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Order NO. D198295
小鼠抗ANPEP单克隆抗体
英文名 Anti-ANPEP mouse monoclonal antibody
别名 APN; CD13; GP150; LAP1; P150; PEPN
相关类别 一抗 储存 冷冻(-20℃) 避光
宿主 Mouse 反应种属 Human
克隆类型 mouse monoclonal 抗原 ANPEP
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D198295-0100 100 ul 预计5日内发货
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产品描述

概述

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma.

应用

免疫印迹(WB),免疫组织化学(IHC)

属性

保存缓冲液 PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
运输条件 2-8°C
靶点 Uniprot 登记号 P15144
靶点基因 ID 290
靶点全称 alanyl aminopeptidase, membrane
靶点别名 APN; CD13; LAP1; P150; PEPN; GP150
靶点研究领域 Immunology, Stem Cells
亚型 IgG2a
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded human colon tissue, on the right is immunohistochemistry of paraffin-embedded human pancreas tissue using D198295(ANPEP Antibody) at dilution 1/40. (Original magnification: ×200)


  • The image on the left is immunohistochemistry of paraffin-embedded human prostate tissue, on the right is immunohistochemistry of paraffin-embedded human tonsil tissue using D198295(ANPEP Antibody) at dilution 1/40. (Original magnification: ×200)


  • Gel: 8%SDS-PAGE, Lysate: 35μg, Lane 1-9: HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC-12 and MCF7 cell lysates , Primary antibody: D198295(ANPEP Antibody) at dilution 1/200, Secondary antibody: Goat anti mouse IgG at 1/8000 dilution, Exposure time: 15 minutes
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