Order NO. D198986
产品描述
概述
Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
应用
免疫印迹（WB），免疫组织化学（IHC），免疫荧光（IF）
属性
| 保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
Q8WYR1
|
| 靶点基因 ID |
23533
|
| 靶点全称 |
phosphoinositide-3-kinase regulatory subunit 5
|
| 靶点别名 |
p101; FOAP-2; P101-PI3K; F730038I15Rik
|
| 靶点研究领域 |
Signal Transduction
|
| 亚型 |
IgG2b
|
