Order NO. D199321
产品描述
概述
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
应用
免疫印迹(WB),免疫组织化学(IHC),免疫荧光(IF),流式细胞术(FCM)
属性
保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q8N9N2
|
靶点基因 ID |
51008
|
靶点全称 |
activating signal cointegrator 1 complex subunit 1
|
靶点别名 |
p50; CGI-18; SMABF2; ASC1p50
|
靶点研究领域 |
Signal Transduction
|
亚型 |
IgG1
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