Order NO. D199442
产品描述
概述
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
应用
免疫印迹（WB），免疫组织化学（IHC），免疫荧光（IF），流式细胞术（FCM）
属性
| 保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P04637
|
| 靶点基因 ID |
7157
|
| 靶点全称 |
tumor protein p53
|
| 靶点别名 |
P53; BCC7; LFS1; BMFS5; TRP53
|
| 靶点研究领域 |
Cell Biology, Epigenetics and Nuclear Signaling, Cancer
|
| 亚型 |
IgG1
|
