Order NO. D199519
产品描述
概述
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
应用
免疫印迹（WB），免疫组织化学（IHC），免疫荧光（IF），流式细胞术（FCM）
属性
| 保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P35222
|
| 靶点基因 ID |
1499
|
| 靶点全称 |
catenin beta 1
|
| 靶点别名 |
EVR7; CTNNB; MRD19; NEDSDV; armadillo
|
| 靶点研究领域 |
Signal Transduction, Neuroscience, Cardiovascular
|
| 亚型 |
IgG1
|
