Order NO. D199675
产品描述
概述
Myo-inositol oxygenase (MIOX), also known as ALDRL6, is a renal-specific member of the Aldo-keto reductase family. It catalyzes the first committed step in the Myo-inositol metabolism pathway and is widely distributed in mammalian tissues. Human Myo-inositol oxygenase shares 91% and 96% sequence homology with mouse and pig Myo-inositol oxygenase homologs, respectively. Myo-inositol oxygenase is responsible for the oxidative cleavage of Myo-inositol (MI) and its epimer D-chiro inositol (DCI) to D-glucuronate. The dioxygen-dependent cleavage of the C1-C6 bond in Myo-inositol is accomplished through the utilization of the Fe(II)/Fe(III) binuclear iron center of MIOX. Myo-inositol oxygenase has also been implicated in complications of diabetes, including diabetic nephropathy.
应用
免疫印迹（WB），免疫组织化学（IHC），免疫荧光（IF），流式细胞术（FCM）
属性
| 保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
Q9UGB7
|
| 靶点基因 ID |
55586
|
| 靶点全称 |
myo-inositol oxygenase
|
| 靶点别名 |
ALDRL6
|
| 靶点研究领域 |
Metabolism
|
| 亚型 |
IgG2a
|
