Order NO. D199693
产品描述
概述
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit, and the 52-kD EIF2-gamma subunit. The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
应用
免疫印迹(WB),免疫组织化学(IHC),免疫荧光(IF),流式细胞术(FCM)
属性
保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P05198
|
靶点基因 ID |
1965
|
靶点全称 |
eukaryotic translation initiation factor 2 subunit alpha
|
靶点别名 |
EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha
|
靶点研究领域 |
Epigenetics and Nuclear Signaling
|
亚型 |
IgG1
|