概述

Tristetraprolin (TTP), also known as Nup475 and TIS11, is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. Stimulation of quiescent fibroblasts by mitogens, including platelet derived growth factor and fibroblast growth factor, results in the serine phosphorylation of TTP and the rapid redistribution of the protein from the nucleus to the cytoplasm. In vitro studies have demonstrated that TTP is phosphorylated by p42 MAP kinase, indicating that the activity of TTP may be regulated by the MAP kinase pathway in vivo. Knockout mice deficient in TTP develop autoimmunity, inflammatory arthritis and dermatitis. These conditions can be reversed by blocking the activity of the inflammatory mediator, tumor necrosis factor-alpha (TNF-α), suggesting that TTP may function to negatively regulate the expression of TNF-a.

应用

免疫印迹（WB），免疫组织化学（IHC），免疫荧光（IF），流式细胞术（FCM）

属性

保存缓冲液	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
运输条件	2-8°C
靶点 Uniprot 登记号	P26651
靶点基因 ID	7538
靶点全称	ZFP36 ring finger protein
靶点别名	TTP; G0S24; GOS24; TIS11; NUP475; zfp-36; RNF162A
靶点研究领域	Signal Transduction, Epigenetics and Nuclear Signaling, Neuroscience, Immunology
亚型	IgG1