Order NO. D199929
产品描述
概述
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
应用
免疫印迹(WB)
属性
保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P52945
|
靶点基因 ID |
3651
|
靶点全称 |
pancreatic and duodenal homeobox 1
|
靶点别名 |
GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1; PAGEN1
|
靶点研究领域 |
Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Metabolism, Cardiovascular, Developmental Biology
|
亚型 |
IgG1
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