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| 编 号 | 规格 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D220091-0025 | 25 ul | 现货 | 待询价 | 待询价 |
|
| D220091-0100 | 100 ul | 现货 | 待询价 | 待询价 |
|
| D220091-0200 | 200 ul | 现货 | 待询价 | 待询价 |
|
概述
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | P38936 |
| 靶点基因 ID | 1026 |
| 靶点全称 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| 靶点别名 | P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 |
| 靶点研究领域 | Epigenetics and Nuclear Signaling, Cancer |
| 亚型 | Immunogen-specific rabbit IgG |
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