Order NO. D220162
产品描述
概述
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
应用
酶联免疫吸附测定(ELISA),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q13651
|
靶点基因 ID |
3587
|
靶点全称 |
Interleukin-10 receptor subunit alpha
|
靶点别名 |
CD210, IL10R, CD210a, CDW210A, HIL-10R, IL-10R1
|
靶点研究领域 |
Immunology
|
亚型 |
Immunogen-specific rabbit IgG
|