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Order NO. D220721
兔抗GREM1多克隆抗体
英文名 Anti-GREM1 rabbit polyclonal antibody
别名 DRM; PIG2; DAND2; IHG-2; GREMLIN; CKTSF1B1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 GREM1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D220721-0025 25 ul 现货
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D220721-0100 100 ul 现货
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D220721-0200 200 ul 现货
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产品描述

概述

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 O60565
靶点基因 ID 26585
靶点全称 gremlin 1, DAN family BMP antagonist
靶点别名 DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
靶点研究领域 Signal Transduction, Stem Cells
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Mouse small intestines tissue, TM4, Mouse brain tissue, LOVO, SKOV3, MCF-7 cell, Mouse kidney tissue lysates, Primary antibody: D220721(GREM1 Antibody) at dilution 1/700, Secondary antibody: D110058(HRP-conjugated Goat anti rabbit IgG) at 1/5000 dilution, Exposure time: 10 seconds
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