Order NO. D223285
产品描述
概述
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
应用
酶联免疫吸附测定(ELISA),免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
O43318
|
靶点基因 ID |
6885
|
靶点全称 |
mitogen-activated protein kinase kinase kinase 7
|
靶点别名 |
CSCF; FMD2; TAK1; MEKK7; TGF1a
|
靶点研究领域 |
Signal Transduction, Cardiovascular, Immunology
|
亚型 |
Immunogen-specific rabbit IgG
|