网 站
反 馈
网 站
指 南
Order NO. D225080
兔抗SHC1多克隆抗体
英文名 Anti-SHC1 rabbit polyclonal antibody
别名 SHC adaptor protein 1; SHC; SHCA
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 SHC1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D225080-0025 25 ul 现货
加入购物车
D225080-0100 100 ul 现货
加入购物车
D225080-0200 200 ul 现货
加入购物车
产品描述

概述

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 P29353
靶点基因 ID 6464
靶点全称 SHC adaptor protein 1
靶点别名 SHC; SHCA
靶点研究领域 Signal Transduction, Neuroscience
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using D225080(SHC1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)


  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Hela, HEPG2, NIH/3T3, 293T, Jurkat, RAW264.7 and 231 cell lysates, Primary antibody: D225080(SHC1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
    我的购物车(0) 结算