Order NO. D225915
产品描述
概述
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
应用
酶联免疫吸附测定(ELISA),免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P43403
|
靶点基因 ID |
7535
|
靶点全称 |
zeta chain of T cell receptor associated protein kinase 70
|
靶点别名 |
SRK; STD; TZK; STCD; IMD48; ADMIO2; ZAP-70
|
靶点研究领域 |
Signal Transduction, Immunology
|
亚型 |
Immunogen-specific rabbit IgG
|