Order NO. D260801
产品描述
概述
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
O95342
|
| 靶点基因 ID |
8647
|
| 靶点全称 |
ATP-binding cassette, sub-family B (MDR/TAP), member 11
|
| 靶点别名 |
BSEP; PGY4; SPGP; ABC16; BRIC2; PFIC2; PFIC-2
|
| 靶点研究领域 |
Metabolism, Cancer
|
| 亚型 |
Immunogen-specific rabbit IgG
|
