Order NO. D261532
产品描述
概述
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P25942
|
| 靶点基因 ID |
958
|
| 靶点全称 |
CD40 molecule, TNF receptor superfamily member 5
|
| 靶点别名 |
p50; Bp50; CDW40; TNFRSF5
|
| 靶点研究领域 |
Cardiovascular, Immunology, Stem Cells
|
| 亚型 |
Immunogen-specific rabbit IgG
|
