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Order NO. D262023
兔抗KDM4B多克隆抗体
英文名 Anti-KDM4B rabbit polyclonal antibody
别名 JMJD2B; TDRD14B
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human
克隆类型 rabbit polyclonal 抗原 KDM4B
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D262023-0025 25 ul 现货
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D262023-0100 100 ul 现货
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D262023-0200 200 ul 现货
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产品描述

概述

JMJD2B (JmjC domain-containing histone demethylation protein 3A) is a 1,064 amino acid protein encoded by the human gene JMJD2B. JMJD2B belongs to the JMJD2B histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. The two Tudor domains recognize and bind methylated histones and have an interdigitated structure; the unusual fold is required for its ability to bind methylated histone tails. JMJD2B is a histone demethylase that specifically demethylates Lys 9 residues of Histone H3, thereby playing a role in histone code. It does not demethylate Histone H3 Lys 4, H3 Lys 27, H3 Lys 36 or H4 Lys 20, however, and is only able to demethylate trimethylated H3 Lys-9 and has weaker activity than JMJD2A, JMJD2C and JMJD2D. JMJD2B demethyl-ation of Lysine residues will generate formaldehyde and succinate. JMJD2B is a ubiquitously expressed nuclear protein.

应用

酶联免疫吸附测定(ELISA),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 O94953
靶点基因 ID 23030
靶点全称 lysine (K)-specific demethylase 4B
靶点别名 JMJD2B; TDRD14B
靶点研究领域 Epigenetics and Nuclear Signaling
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using D262023(KDM4B Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)


  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using D262023(KDM4B Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

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