Order NO. D263508
兔抗TNFSF11多克隆抗体
| 英文名 | Anti-TNFSF11 rabbit polyclonal antibody | ||
| 别名 | ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse, Rat |
| 标记物 | Unconjugate | 克隆类型 | rabbit polyclonal |
| 抗原 | TNFSF11 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D263508-0025 | 25 ul | 现货 |
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| D263508-0100 | 100 ul | 现货 |
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| D263508-0200 | 200 ul | 现货 |
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属性
| Background: | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] (The background information is obtained from official databases and does not represent the product information.) |
| Applications: | ELISA, WB, IHC |
| Name of antibody: | TNFSF11 |
| Immunogen: | Synthetic peptide of human TNFSF11 |
| Full name: | TNF superfamily member 11 |
| Synonyms: | ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2 |
| SwissProt: | O14788 |
| ELISA Recommended dilution: | 5000-10000 |
| IHC positive control: | Human liver cancer |
| IHC Recommend dilution: | 30-150 |
| WB Predicted band size: | 36 kDa |
| WB Positive control: | Mouse liver tissue, Mouse lung tissue, Jurkat cell, K562 cell lysates |
| WB Recommended dilution: | 500-2000 |
相关文档
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Sample Application
