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Order NO. D263508
兔抗TNFSF11多克隆抗体
英文名 Anti-TNFSF11 rabbit polyclonal antibody
别名 ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
标记物 Unconjugate 克隆类型 rabbit polyclonal
抗原 TNFSF11    
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D263508-0025 25 ul 现货
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D263508-0100 100 ul 现货
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D263508-0200 200 ul 现货
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属性

Background: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] (The background information is obtained from official databases and does not represent the product information.)
Applications: ELISA, WB, IHC
Name of antibody: TNFSF11
Immunogen: Synthetic peptide of human TNFSF11
Full name: TNF superfamily member 11
Synonyms: ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2
SwissProt: O14788
ELISA Recommended dilution: 5000-10000
IHC positive control: Human liver cancer
IHC Recommend dilution: 30-150
WB Predicted band size: 36 kDa
WB Positive control: Mouse liver tissue, Mouse lung tissue, Jurkat cell, K562 cell lysates
WB Recommended dilution: 500-2000
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using D263508(TNFSF11 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)


  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Mouse liver tissue, Mouse lung tissue, Jurkat cell, K562 cell lysates, Primary antibody: D263508(TNFSF11 Antibody) at dilution 1/400, Secondary antibody: D110058(HRP-conjugated Goat anti rabbit IgG) at 1/5000 dilution, Exposure time: 1 minute
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