Order NO. D290114
兔抗ATF6单克隆抗体
| 英文名 | Anti-ATF6 rabbit monoclonal antibody | ||
| 别名 | activating transcription factor 6; ACHM7; ATF6A | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human |
| 标记物 | Unconjugate | 克隆类型 | rabbit monoclonal |
| 抗原 | ATF6 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D290114-0050 | 50 ul | 预计5日内发货 |
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| D290114-0100 | 100 ul | 预计5日内发货 |
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属性
| Background: | This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011] |
| Applications: | WB |
| Name of antibody: | ATF6 |
| Immunogen: | Fusion protein of human ATF6 |
| Full name: | activating transcription factor 6 |
| Synonyms: | ACHM7; ATF6A |
| SwissProt: | P18850 |
| WB Predicted band size: | 75 kDa |
| WB Positive control: | A549, HL-60, U2OS lysates |
| WB Recommended dilution: | 500-2000 |
相关文档
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Sample Application
